Overview

  • Product name

    Endothall, protein phosphatase 2A (PP2A) inhibitor
  • Description

    Potent, selective protein phosphatase 2A (PP2A) inhibitor
  • Biological description

    Potent, selective protein phosphatase 2A (PP2A) inhibitor (IC50 = 90 nM). Also inhibits protein phosphatase 1 (PP1) (IC50= 5 μM).
  • Purity

    > 98%
  • CAS Number

    145-73-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Shao J & Diamond MI Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. PLoS One 7:e32802 (2012). Read more (PubMed: 22479341) »
  • Knapp J  et al. Contractility and inhibition of protein phosphatases by cantharidin. Gen Pharmacol 31:729-33 (1998). Read more (PubMed: 9809469) »
  • Erdödi F  et al. Endothall thioanhydride inhibits protein phosphatases-1 and -2A in vivo. Am J Physiol 269:C1176-84 (1995). Read more (PubMed: 7491907) »
  • Li YM  et al. Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues. Biochem Pharmacol 46:1435-43 (1993). Read more (PubMed: 8240393) »

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