Overview

  • Product name
    Anti-Endothelin 3 antibody
    See all Endothelin 3 primary antibodies
  • Description
    Rabbit polyclonal to Endothelin 3
  • Host species
    Rabbit
  • Specificity
    This antibody detects endogenous levels of total Endothelin 3 protein.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Fusion protein within Human Endothelin 3 (internal sequence). The exact sequence is proprietary. The identity of the protein fusion partner is GST.
    Database link: P14138

  • Positive control
    • Human esophagus and thyroid cancer tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab197374 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Function
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • Tissue specificity
    Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
  • Involvement in disease
    Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
    Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
  • Sequence similarities
    Belongs to the endothelin/sarafotoxin family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • EDN3 antibody
    • EDN3_HUMAN antibody
    • Endothelin-3 antibody
    • ET 3 antibody
    • ET-3 antibody
    • PPET3 antibody
    • Preproendothelin 3 antibody
    • Preproendothelin-3 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue, labeling Endothelin 3 with ab197374 at 1/30 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue, labeling Endothelin 3 with ab197374 at 1/30 dilution. 

References

ab197374 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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