Anti-Leu Enkephalin antibody [NOC1] (ab150346)
Key features and details
- Mouse monoclonal [NOC1] to Leu Enkephalin
- Suitable for: IHC-Fr, ICC, RIA, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG1
Overview
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Product name
Anti-Leu Enkephalin antibody [NOC1] -
Description
Mouse monoclonal [NOC1] to Leu Enkephalin -
Host species
Mouse -
Specificity
This antibody does not distinguish between Met-enkephalin and Leu-enkephalin by radioimmunoassay or by immunocytochemistry.
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Tested applications
Suitable for: IHC-Fr, ICC, RIA, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide corresponding to Leu Enkephalin conjugated to bovine serum albumin.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Contains no additives. -
Concentration information loading...
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Purity
Tissue culture supernatant -
Purification notes
ab150346 is in a protein-free culture medium. -
Clonality
Monoclonal -
Clone number
NOC1 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab150346 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-Fr |
Use at an assay dependent concentration.
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ICC |
Use at an assay dependent concentration.
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RIA |
Use at an assay dependent concentration.
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IHC-P | (1) |
Use at an assay dependent concentration.
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Notes |
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IHC-Fr
Use at an assay dependent concentration. |
ICC
Use at an assay dependent concentration. |
RIA
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
Target
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Relevance
Enkephalin and enkephalin-like peptides have been detected in many animal species. In mammals these opioid pentapeptides are cleaved from a common precursor molecule which is expressed in a number of cell types, including neurons and endocrine cells associated with the sympathetic nervous system where they are often co-stored with catecholamines. They are known to be endogenous ligands for Sopioid receptors and are known to mediate analgesia at the spinal level. -
Cellular localization
Secreted -
Database links
- Entrez Gene: 5179 Human
- Entrez Gene: 18619 Mouse
- Entrez Gene: 29237 Rat
- Omim: 131330 Human
- SwissProt: P01210 Human
- SwissProt: P22005 Mouse
- SwissProt: P04094 Rat
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Alternative names
- PENK antibody
- Proenkephalin A antibody
- Proenkephalin antibody
Protocols
Datasheets and documents
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Datasheet download
References (9)
ab150346 has been referenced in 9 publications.
- Nestor-Kalinoski A et al. Unique Neural Circuit Connectivity of Mouse Proximal, Middle, and Distal Colon Defines Regional Colonic Motor Patterns. Cell Mol Gastroenterol Hepatol 13:309-337.e3 (2022). PubMed: 34509687
- Gao T et al. G-Protein-Coupled Estrogen Receptor (GPER) in the Rostral Ventromedial Medulla Is Essential for Mobilizing Descending Inhibition of Itch. J Neurosci 41:7727-7741 (2021). PubMed: 34349001
- Cao F et al. Integration of Transcriptome Resequencing and Quantitative Proteomics Analyses of Collagenase VII-Induced Intracerebral Hemorrhage in Mice. Front Genet 11:551065 (2020). PubMed: 33424913
- Oliver RJ et al. Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration. Brain Sci 9:N/A (2019). PubMed: 31752398
- Tang D et al. High expression of proenkephalin is associated with favorable outcomes in patients with gastrointestinal stromal tumors. Cancer Manag Res 11:6681-6690 (2019). PubMed: 31410059
- Kiss A & Osacka J Spatial relationship between the c-Fos distribution and enkephalinergic, substance P, and tyrosine hydroxylase innervation fields after acute treatment with neuroleptics olanzapine, amisulpride, quetiapine, and aripiprazole in the rat septum. Endocr Regul 53:165-177 (2019). PubMed: 31517634
- Zheng C et al. TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect. Front Cell Neurosci 12:417 (2018). PubMed: 30555300
- Mu S et al. Protein regulation of induced pluripotent stem cells by transplanting in a Huntington's animal model. Neuropathol Appl Neurobiol 42:521-34 (2016). PubMed: 26859760
- Cuello AC et al. Characterization and immunocytochemical application of monoclonal antibodies against enkephalins. J Histochem Cytochem 32:947-57 (1984). PubMed: 6086744