Key features and details
- Selective protease-activated receptor 2 (PAR2) anatagonist
- CAS Number: 789488-77-3
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameENMD-1068, protease-activated receptor 2 (PAR2) anatagonist
DescriptionSelective protease-activated receptor 2 (PAR2) anatagonist
Selective protease-activated receptor 2 (PAR2) antagonist (IC50 = 1.2 mM). Anti-inflamatory agent. Active in vivo and in vitro.
Chemical name6-Amino-1-[4-(3-methyl-1-oxybutyl)-1-piperazinyl]-1-hexanone hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141699 has been referenced in 2 publications.
- Zhang X et al. Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer. Am J Cancer Res 9:1995-2006 (2019). PubMed: 31598400
- Roman K et al. Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome. Pain 155:1328-38 (2014). PubMed: 24726923