Overview

  • Product name

  • Description

    Rabbit polyclonal to ENOX2/tNOX
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IF, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human ENOX2/tNOX aa 200-610 (C terminal).
    Database link: Q16206

  • Positive control

    • WB: Extracts from MCF7, THP-1, SW480, Jurkat, SKOV3, mouse liver, kidney and ovary and rat liver. ICC/IF: U20S cells.
  • General notes

    Previously labelled as ENOX2. 

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab210751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 70 kDa.
ICC/IF 1/50 - 1/100.
IHC-P 1/50 - 1/200.

Target

  • Function

    May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock.
  • Tissue specificity

    Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells.
  • Sequence similarities

    Belongs to the ENOX family.
    Contains 1 RRM (RNA recognition motif) domain.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Cell membrane. Secreted > extracellular space. Extracellular and plasma membrane-associated.
  • Information by UniProt
  • Database links

  • Alternative names

    • APK1 antibody
    • APK1 antigen antibody
    • COVA1 antibody
    • Cytosolic ovarian carcinoma antigen 1 antibody
    • Ecto NOX disulfide thiol exchanger 2 antibody
    • ENOX 2 antibody
    • ENOX2 antibody
    • ENOX2_HUMAN antibody
    • OTTHUMP00000024021 antibody
    • OTTHUMP00000024022 antibody
    • Protein disulfide-thiol oxidoreductase antibody
    • tNOX antibody
    • Tumor associated hydroquinone oxidase antibody
    • Tumor-associated hydroquinone oxidase antibody
    see all

Images

  • All lanes : Anti-ENOX2/tNOX antibody (ab210751) at 1/500 dilution

    Lane 1 : Extracts from MCF7 cell line
    Lane 2 : Extracts from THP-1 cell line
    Lane 3 : Extracts from SW480 cell line
    Lane 4 : Extracts from Jurkat cell line
    Lane 5 : Extracts from SKOV3 cell line
    Lane 6 : Extracts from mouse liver
    Lane 7 : Extracts from mouse kidney
    Lane 8 : Extracts from mouse ovary
    Lane 9 : Extracts from rat liver

    Predicted band size: 70 kDa

  • Immunofluorescence analysis of MCF7 cells labeling ENOX2/tNOX with ab210751 at a 1/50 dilution (red). Nuclei were counterstained with DAPI (blue).

  • Immunofluorescence analysis of U20S cells labeling ENOX2/tNOX with ab210751 at a 1/50 dilution (red). Nuclei were counterstained with DAPI (blue).

References

ab210751 has not yet been referenced specifically in any publications.

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