Enoxacin, TAR RNA-binding protein 2 activator. (ab143281)

Overview

  • Product name

    Enoxacin, TAR RNA-binding protein 2 activator.
  • Description

    Broad-spectrum antibiotic agent. TAR RNA-binding protein 2 activator.
  • Biological description

    Broad-spectrum antibiotic agent. TAR RNA-binding protein 2 activator. Inhibits DNA gyrase. Enhances the production of miRNAs and shows antitumor effects in vivo. Blood-brain barrier permeable. Orally active.
  • Purity

    > 99%
  • CAS Number

    74011-58-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Smalheiser NR  et al. Enoxacin Elevates MicroRNA Levels in Rat Frontal Cortex and Prevents Learned Helplessness. Front Psychiatry 5:6 (2014). Read more (PubMed: 24575053) »
  • Kodawara T  et al. Inhibitory effect of ciprofloxacin on ß-glucuronidase-mediated deconjugation of mycophenolic acid glucuronide. Biopharm Drug Dispos : (2014). Read more (PubMed: 24615849) »
  • Melo S  et al. Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A 108:4394-9 (2011). Read more (PubMed: 21368194) »

Customer reviews and Q&As

Answer

As stated on the datasheet, ab143281 is soluble in 1 M NaOH to 100 mM.

I have also found some other information in the literature with regards to it's solubility in other buffers: Soluble in water (Partly), 1 M NaOH (50 mg/ml, Yellow, Clear to Slightly Hazy), DMSO (Sparingly), chloroform (Sparingly), and methanol (Sparingly).

The amount of product required depends on many factors including target accessibility, cell permeability, duration of incubation, and type of cells or assay used, it is best to survey the literature to determine the IC50, EC50 or Ki. For an inhibitor, if published Ki or, IC50 values are known, we recommend that you use 5 to 10 times higher than these values to maximally inhibit enzyme or receptor activity. If there are no published values we recommend that you perform dose-response experiments (running appropriate controls) and use Michaelis-Menten kinetics to determine the Ki value.

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