Enramycin B (Enduracidin B), Lipodepsipeptide antibiotic agent (ab143613)

Overview

  • Product name

    Enramycin B (Enduracidin B), Lipodepsipeptide antibiotic agent
  • Description

    Lipodepsipeptide antibiotic agent. MurG inhibitor.
  • Biological description

    Lipodepsipeptide antibiotic agent. MurG inhibitor. Inhibits peptidoglycan synthesis. Active against multi-drug resistant Gram-positive bacteria in vivo.
  • Purity

    >= 83%
  • CAS Number

    34304-21-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-N-[(2Z,4E)-10-Methyl-1-oxo-2,4-undecadien-1-yl]-L-α-aspartyl-L-threonyl-(2R)-2-(4-hydroxyphenyl)glycyl-D-ornithyl-D-allothreonyl-(2S)-2-(4-hydroxyphenyl)glycyl-(2R)-2-(4-hydroxyphenyl)glycyl-L-allothreonyl-N5-(aminocarbonyl)-L-ornithyl-3-[(5R)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-D-alanyl-(2S)-2-(4-hydroxyphenyl)glycyl-D-seryl-(2S)-2-(3,5-dichloro-4-hydroxyphenyl)glycylglycyl-3-[(5R)-2-amino-4,5-dihydro-1H-imidazol-5-yl]-L-alanyl-D-alanyl-2-(4-hydroxyphenyl)

  • Molecular weight

    2369.33
  • Molecular formula

    C108H140Cl2N26O31
  • PubChem identifier

    16132291
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 0.1% formic acid in H2O

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(C)CCCCC=CC=CC(=O)NC(CC(=O)O)C(=O)NC1C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)C2=CC=C(C=C2)O)CCCN)C(C)O)C3=CC=C(C=C3)O)C4=CC=C(C=C4)O)C(C)O)CCCNC(=O)N)CC5CNC(=N5)N)C6=CC=C(C=C6)O)CO)C7=CC(=C(C(=C7)Cl)O)Cl)CC8CNC(=N8)N)C)C9=CC=C(C=C9)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Inoue K  et al. An approach to on-line electrospray mass spectrometric detection of polypeptide antibiotics of enramycin for high-speed counter-current chromatographic separation. J Pharm Biomed Anal 51:1154-60 (2010). Read more (PubMed: 20004073) »
  • Yin X  et al. Enduracidin analogues with altered halogenation patterns produced by genetically engineered strains of Streptomyces fungicidicus. J Nat Prod 73:583-9 (2010). Read more (PubMed: 20353165) »
  • Castiglione F  et al. Structure elucidation and 3D solution conformation of the antibiotic enduracidin determined by NMR spectroscopy and molecular dynamics. Magn Reson Chem 43:603-10 (2005). Read more (PubMed: 15986494) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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