Overview

  • Product name

  • Description

    Rabbit polyclonal to ENTPD5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment within Human ENTPD5 aa 1-191. The exact sequence is proprietary. (NP_001240.1).
    Database link: O75356

  • Positive control

    • Human kidney tissue; A431, H1299 and HeLa whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab189406 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 48 kDa.
IHC-P Use a concentration of 10 µg/ml.

Target

  • Function

    Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
  • Tissue specificity

    Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.
  • Pathway

    Protein modification; protein glycosylation.
  • Sequence similarities

    Belongs to the GDA1/CD39 NTPase family.
  • Post-translational
    modifications

    N-glycosylated; high-mannose type.
  • Cellular localization

    Endoplasmic reticulum lumen.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD39 like 4 antibody
    • AI196558 antibody
    • AI987697 antibody
    • CD39 antigen like 4 antibody
    • CD39 antigen-like 4 antibody
    • CD39 like 4 antibody
    • CD39L4 antibody
    • Ectonucleoside triphosphate diphosphohydrolase 5 antibody
    • ENTP5_HUMAN antibody
    • Entpd5 antibody
    • ER UDPase antibody
    • ER-UDPase antibody
    • GDPase ENTPD5 antibody
    • Guanosine-diphosphatase ENTPD5 antibody
    • MGC163357 antibody
    • MGC163359 antibody
    • mNTPase antibody
    • NTPDase 5 antibody
    • Nucleoside diphosphatase antibody
    • PCPH antibody
    • Pcph proto oncogene protein antibody
    • Proto oncogene CPH antibody
    • UDPase ENTPD5 antibody
    • Uridine-diphosphatase ENTPD5 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling ENTPD5 with ab189406 at 10 µg/ml.

  • All lanes : Anti-ENTPD5 antibody (ab189406) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : HeLa whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 48 kDa



    10% SDS PAGE.

References

ab189406 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab189406.
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