Overview

  • Product name

    Anti-EPB41 antibody
  • Description

    Rabbit polyclonal to EPB41
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human EPB41 aa 210-500.
    Database link: P11171

  • Positive control

    • 293T cell lysate; mouse brain and liver lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab185704 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 97 kDa.
IHC-P 1/50 - 1/200.
ICC/IF Use at an assay dependent concentration.

Target

  • Function

    Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes.
  • Involvement in disease

    Defects in EPB41 are the cause of elliptocytosis type 1 (EL1) [MIM:611804]. EL1 is a Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant, hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape.
    Defects in EPB41 are a cause of hereditary pyropoikilocytosis (HPP) [MIM:266140]. HPP is an autosomal recessive hematologic disorder characterized by hemolytic anemia, microspherocytosis, poikilocytosis, and an unusual thermal sensitivity of red cells.
  • Sequence similarities

    Contains 1 FERM domain.
  • Post-translational
    modifications

    Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.
    Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex.
    O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
  • Cellular localization

    Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • 4.1R antibody
    • 41_HUMAN antibody
    • Band 4.1 antibody
    • E41P antibody
    • EL 1 antibody
    • EL1 antibody
    • EL1 gene antibody
    • Elliptocytosis 1 antibody
    • Elliptocytosis 1 RH linked antibody
    • EPB 4.1 antibody
    • EPB 41 antibody
    • EPB4.1 antibody
    • Epb41 antibody
    • Erythrocyte membrane protein band 4.1 (elliptocytosis 1 RH linked) antibody
    • Erythrocyte membrane protein band 4.1 antibody
    • Erythrocyte surface protein band 4.1 antibody
    • HE antibody
    • P4.1 antibody
    • Protein 4.1 antibody
    • Protein 4.1, red blood cell type antibody
    see all

Images

  • Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab185704. Blue DAPI for nuclear staining.
  • All lanes : Anti-EPB41 antibody (ab185704) at 1/500 dilution

    Lane 1 : 293T cell lysate
    Lane 2 : mouse brain lysate
    Lane 3 : mouse liver lysate

    Predicted band size: 97 kDa

References

ab185704 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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