Key features and details
- Rabbit polyclonal to EPB42
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-EPB42 antibody
DescriptionRabbit polyclonal to EPB42
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
- IHC-P: Human gallbladder tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab243449 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionProbably plays an important role in the regulation of erythrocyte shape and mechanical properties.
Involvement in diseaseDefects in EPB42 are the cause of spherocytosis type 5 (SPH5) [MIM:612690]; also known as hereditary spherocytosis type 5 (HS5). Spherocytosis is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. Absence of band 4.2 associated with spur or target erythrocytes has also been reported.
Sequence similaritiesBelongs to the transglutaminase superfamily. Transglutaminase family.
modificationsBoth cAMP-dependent kinase (CAPK) and another kinase present in the red-blood cells seem to be able to phosphorylate EPB42.
Cellular localizationCell membrane. Cytoplasm > cytoskeleton. Cytoplasmic surface of erythrocyte membranes.
- Information by UniProt
- EPB42 antibody
- EPB42_HUMAN antibody
- Erythrocyte membrane protein band 4.2 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab243449 has not yet been referenced specifically in any publications.