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  1. Link

    eph-receptor-a5bsk-antibody-ab136116.pdf

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Cardiovascular Angiogenesis Ephrins Eph Receptors
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Anti-Eph receptor A5/BSK antibody (ab136116)

  • Datasheet
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  • Western blot - Anti-Eph receptor A5/BSK antibody (ab136116)

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Primary

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Protein

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  • Datasheet
  • References
  • Protocols

Overview

  • Product name

    Anti-Eph receptor A5/BSK antibody
    See all Eph receptor A5/BSK primary antibodies
  • Description

    Rabbit polyclonal to Eph receptor A5/BSK
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human Eph receptor A5/BSK (internal sequence).

  • Positive control

    • HeLa cell lysate.
  • General notes

     This product was previously labelled as Eph receptor A5

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
    Note: PBS is without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab136116 was affinity-purified from rabbit antiserum by immunogenic peptide affinity-chromatography.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Angiogenesis
    • Ephrins
    • Eph Receptors
    • Neuroscience
    • Neurotransmission
    • Intracellular Signaling
    • Kinases
    • Neuroscience
    • Cell Type Marker
    • Neuron marker
    • Growth Cone
    • Neuroscience
    • Neurology process
    • Growth and Development
    • Axonal Guidance Proteins
    • Neuroscience
    • Neurotransmission
    • Receptors / Channels
    • Tyrosine Kinase Receptors

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • HeLa whole cell lysate (ab29545)
    • HeLa membrane extract lysate (ab29547)
  • Recombinant Protein

    • Recombinant Human Eph receptor A5/BSK protein (ab158372)

Applications

Our Abpromise guarantee covers the use of ab136116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 115 kDa.

Target

  • Function

    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
  • Tissue specificity

    Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
    Contains 1 Eph LBD (Eph ligand-binding) domain.
    Contains 2 fibronectin type-III domains.
    Contains 1 protein kinase domain.
    Contains 1 SAM (sterile alpha motif) domain.
  • Post-translational
    modifications

    Phosphorylated. Phosphorylation is stimulated by the ligand EFNA5. Dephosphorylation upon stimulation by glucose, inhibits EPHA5 forward signaling and results in insulin secretion.
  • Cellular localization

    Cell membrane. Cell projection > axon. Cell projection > dendrite.
  • Target information above from: UniProt accession P54756 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 2044 Human
    • Entrez Gene: 13839 Mouse
    • Entrez Gene: 79208 Rat
    • Omim: 600004 Human
    • SwissProt: P54756 Human
    • SwissProt: Q60629 Mouse
    • SwissProt: P54757 Rat
    • Unigene: 654492 Human
    • Unigene: 137991 Mouse
    • Unigene: 438006 Mouse
    • Unigene: 24569 Rat
    see all
  • Alternative names

    • Brain-specific kinase antibody
    • bsk antibody
    • CEK 7 antibody
    • Eck like sequence 1 antibody
    • EHK 1 antibody
    • EHK-1 antibody
    • EK7 antibody
    • Els 1 antibody
    • EPH homology kinase 1 antibody
    • EPH-like kinase 7 antibody
    • EPHA5 antibody
    • EPHA5_HUMAN antibody
    • Ephrin type A receptor 5 antibody
    • Ephrin type-A receptor 5 antibody
    • HEK 7 antibody
    • hEK7 antibody
    • Receptor protein tyrosine kinase HEK 7 antibody
    • Rek 7 antibody
    • TYRO 4 antibody
    • Tyrosine protein kinase receptor EHK 1 antibody
    see all

Images

  • Western blot - Anti-Eph receptor A5/BSK antibody (ab136116)
    Western blot - Anti-Eph receptor A5/BSK antibody (ab136116)
    Anti-Eph receptor A5/BSK antibody (ab136116) at 1/500 dilution + HeLa cell lysate at 30 µg

    Predicted band size: 115 kDa

Protocols

  • Western blot protocols

Datasheets and documents

    • Datasheet
  • References

    ab136116 has not yet been referenced specifically in any publications.

    Publishing research using ab136116? Please let us know so that we can cite the reference in this datasheet.

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