Overview

  • Product name

  • Description

    Rabbit polyclonal to Ephexin-5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human Ephexin-5 aa 464-667.
    Database link: O94989

  • Positive control

    • Mouse liver whole cell lysate.
  • General notes

    Keep as concentrated solution.

    Previously labelled as Rho guanine exchange factor 15.

Properties

Applications

Our Abpromise guarantee covers the use of ab127704 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 93 kDa.

Target

  • Function

    Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
  • Tissue specificity

    Expressed in the vascular smooth muscle of coronary artery.
  • Sequence similarities

    Contains 1 DH (DBL-homology) domain.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues upon EFNA1 stimulation.
    Phosphorylation at Tyr-353 by EPHB2 triggers ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation.
  • Cellular localization

    Cell projection > dendrite. Expressed exclusively in dendrites of the developing hippocampus.
  • Information by UniProt
  • Database links

  • Alternative names

    • ARGEF15 antibody
    • ARHGEF15 antibody
    • ARHGF_HUMAN antibody
    • E5 antibody
    • Ephexin-5 antibody
    • Ephexin5 antibody
    • FLJ13791 antibody
    • KIAA0915 antibody
    • MGC44868 antibody
    • Rho guanine exchange factor 15 antibody
    • Rho guanine nucleotide exchange factor (GEF) 15 antibody
    • Rho guanine nucleotide exchange factor 15 antibody
    • Vsm RhoGEF antibody
    • Vsm-RhoGEF antibody
    see all

Images

  • Anti-Ephexin-5 antibody (ab127704) at 1/1000 dilution + Mouse liver whole cell lysate at 50 µg

    Predicted band size: 93 kDa



    7.5% SDS PAGE

References

ab127704 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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