Key features and details
- Rabbit polyclonal to Ephexin-5
- Suitable for: ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Ephexin-5 antibody
See all Ephexin-5 primary antibodies
DescriptionRabbit polyclonal to Ephexin-5
Tested applicationsSuitable for: ICC/IFmore details
Species reactivityReacts with: Human
- HUVEC TERT2 cells.
Previously labelled as Rho guanine exchange factor 15.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab221376 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 0.25 - 2 µg/ml.
Fixation/Permeabilization: PFA/Triton X-100.
FunctionSpecific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.
Tissue specificityExpressed in the vascular smooth muscle of coronary artery.
Sequence similaritiesContains 1 DH (DBL-homology) domain.
modificationsPhosphorylated on tyrosine residues upon EFNA1 stimulation.
Phosphorylation at Tyr-353 by EPHB2 triggers ubiquitination and degradation by the proteasome which promotes EFNB1-dependent synapse formation.
Cellular localizationCell projection > dendrite. Expressed exclusively in dendrites of the developing hippocampus.
- Information by UniProt
- ARGEF15 antibody
- ARHGEF15 antibody
- ARHGF_HUMAN antibody
ab221376 has not yet been referenced specifically in any publications.