Epiandrosterone, Steroid hormone  (ab145698)

Overview

  • Product name

    Epiandrosterone, Steroid hormone 
  • Description

    Steroid hormone with weak androgenic activity; natural metabolite of DHEA
  • Alternative names

    • (3S,5S,8R,9S,10S,13S,14S)-3-Hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-
    • 3beta-Androsterone
    • EPI
    • Epi-Andro
    • Epi-androsterone
    • EpiA
    • Isoandrosterone
    • trans-Androsterone
    see all
  • Biological description

    Steroid hormone with weak androgenic activity. Natural metabolite of dehydroepiandrosterone (DHEA) via the 5α-reductase enzyme. Inhibits the pentose phosphate pathway (PPP). Reversibly blocks L-type calcium channels of ventricular myocytes and inhibits myocardial contractility.

  • Purity

    > 99%
  • CAS Number

    481-29-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3S,5S,8R,9S,10S,13S,14S)-3-Hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
  • Molecular weight

    290.44
  • Molecular formula

    C19H30O2
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • El Kihel L Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports. Steroids 77:10-26 (2012). Read more (PubMed: 22037250) »
  • Gupte SA  et al. Inhibitors of pentose phosphate pathway cause vasodilation: involvement of voltage-gated potassium channels. J Pharmacol Exp Ther 301:299-305 (2002). Read more (PubMed: 11907187) »
  • Gupte SA  et al. Epiandrosterone, a metabolite of testosterone precursor, blocks L-type calcium channels of ventricular myocytes and inhibits myocardial contractility. J Mol Cell Cardiol 34:679-88 (2002). Read more (PubMed: 12054855) »

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