Antibodies to RNA modifications

​​​​Overview

• Working with RNA modifications
• Recombinant technology benefits
• Browse our RNA modification antibody range
• Drugging the epitranscriptome as an effective anti-cancer strategy webinar

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Explore the unexplored 

RNA modifications are out there, but so little is known about their function. That’s why our range of antibodies includes RNA modifications not covered by anyone else. This means you can take your first leap into a new, unexplored area of epigenetics. Discover novel modifications, seek out new meaning and new ideas. Boldly go where no scientist has gone before.

Check out our RNA modification antibody range below.

Find more RNA modification protocols and content here. 

Working with RNA modifications

The field of RNA modifications is relatively new but growing more and more every day. We know that working with these modifications can be tricky. That is why we are adding to our RNA modifications range all the time to get reagents for the newest and most exciting modifications before anyone else. We also know that getting antibodies truly specific to your RNA modification of choice can be difficult, so we use multiple applications to test the specificity of all our antibodies. Check out our RNA modification antibodies control page for more details on what you can do to check that your antibodies work in your model system. 

You can get the best reagents for your RNA modification research right here. Our m6A antibody has been cited in several significant publications, including a Nature Methods paper, which uses it for single-base resolution sequencing of m6A¹. This same m6A antibody also features in a Nature paper, looking at the role of m6A in mRNA stability². Our ac4C antibody was also published in a 2018 Cell paper, which uncovers the role of ac4C in mRNA translation efficiency³. 

The benefits of using recombinant technology

Recombinant RabMAb^®  technology eliminates batch-to-batch variation by using the same immunogen for each round of antibody production. This gives you a consistent antibody and reproducible results throughout your project. Many of our RNA modification antibodies are RabMAb^®  monoclonal antibodies, including key targets such as m6A, m1A, Mettl3, m2,2G, and many more. 

Browse our RNA modification antibody range

Drugging the epitranscriptome as an effective anti-cancer strategy webinar
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Hear about how RNA-modifying enzymes represent a new target class of anti-cancer therapeutics by joining Dr. Konstantinos Tzelepis from the University of Cambridge, UK, as he presents his award-winning work, "Drugging the epitranscriptome as an effective anti-cancer strategy." 

References

1) Linder B  et al. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat Methods 12:767-72 (2015).

2) Mauer J  et al. Reversible methylation of m(6)Am in the 5' cap controls mRNA stability. Nature 541:371-375 (2017).

​3) Arango et al. ​Acetylation of Cytidine in mRNA Promotes
Translation Efficiency. Cell 13;175(7):1872-1886 (2018).