Product nameEpinastine hydrochloride, H1 histamine receptor antagonist
DescriptionAntihistamine. Highly selective, non-sedating H1 histamine receptor antagonist.
- 3-amino-9,13b-dihydro-1H-dibenz [c,f]imidazo[1,5-a]azepine hydrochloride
- 9,13b-Dihydro-1H-dibenz[cf]imidazo[1,5-a]azepine hydrochloride
Antihistamine. Highly selective, non-sedating H1 histamine receptor antagonist. Mast cell stabilizer used in eye drops to treat allergic conjunctivitis.
Chemical name9,13b-Dihydro-1H-dibenz[c,f]imidazo[1,5-a]azepin-3-amine hydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Ariga GG et al. Study of fluorescence interaction and conformational changes of bovine serum albumin with histamine H1 -receptor--drug epinastine hydrochloride by spectroscopic and time-resolved fluorescence methods. Biopolymers 103:646-57 (2015). Read more (PubMed: 26215421) »
- Pradhan S et al. Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects. Expert Opin Drug Metab Toxicol 5:1135-40 (2009). Read more (PubMed: 19630694) »
- Asano K et al. Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro. Mediators Inflamm 2008:265095 (2008). Read more (PubMed: 18725994) »
- Walther G et al. New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine. Arzneimittelforschung 40:440-6 (1990). Read more (PubMed: 1972625) »