Overview

  • Product name

    Epirubicin hydrochloride (Ellence), Topoisomerase II inhibitor
  • Description

    Topoisomerase II inhibitor. Cell-permeable.
  • Biological description

    Topoisomerase II inhibitor (IC50 = 12 μM). Steroisomer of Doxorubicin (Asc 629). Shows antitumor and antiangiogenic activity in vivo. Cell-permeable.
  • Purity

    > 95%
  • CAS Number

    56390-09-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (8S,10S)-10-((3-amino-2,3,6-trideoxy-β-L-arabinohexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride
  • Molecular weight

    579.98
  • Molecular formula

    C27H29NO11.HCl
  • PubChem identifier

    65348
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM (with warming) and in DMSO to 100 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Men Y  et al. The efficacy of mitochondrial targeting antiresistant epirubicin liposomes in treating resistant leukemia in animals. Int J Nanomedicine 6:3125-37 (2011). Read more (PubMed: 22163164) »
  • Landström M  et al. Effect of medroxyprogesterone acetate, alone or in combination with epirubicin hydrochloride, on the growth of the Dunning R3327H prostatic adenocarcinoma. Eur Urol 13:203-6 (1987). Read more (PubMed: 2956111) »
  • Zhang XS  et al. Variable sensitivity of endothelial cells to epirubicin in xenografts of human nasopharyngeal carcinoma CNE-2 cells. Cancer Biol Ther 1:263-5 (0). Read more (PubMed: 12432274) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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