Overview

  • Product name

    Epothilone A, Microtubule-stabilizing agent
  • Description

    Competitive microtubule-stabilizing agent. Potent antiproliferative agent.
  • Biological description

    Competitive microtubule-stabilizing agent (EC0.01 = 2 μM). Potent antiproliferation agent (IC50 = 4.4 nM). Epothilone D (ab143616) and B (ab141271) analog. Induces tubulin polymerization and cell cycle arrest at the G2-M transition. Shows antineoplastic effects.
  • Purity

    > 95%
  • CAS Number

    152044-53-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,5S,6S,7R,10S,14S,16S)-6,10-Dihydroxy-5,7,9,9-tetramethyl-14-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-13,17-dioxabicyclo[14.1.0]heptadecane-8,12-dione
  • Molecular weight

    493.66
  • Molecular formula

    C26H39NO6S
  • PubChem identifier

    448799
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1CCCC2C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Xiao CF  et al. Investigation of inclusion complex of epothilone A with cyclodextrins. Carbohydr Polym 102:297-305 (2014). Read more (PubMed: 24507285) »
  • Sakaushi S  et al. Differential responses of mitotic spindle pole formation to microtubule-stabilizing agents epothilones A and B at low concentrations. Cell Cycle 7:477-83 (2008). Read more (PubMed: 18235240) »
  • Regueiro-Ren A  et al. Synthesis and biological activity of novel epothilone aziridines. Org Lett 3:2693-6 (2001). Read more (PubMed: 11506611) »

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