Epothilone D, Microtubule-stabilizing agent (ab143616)

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Chemical Structure - Epothilone D, Microtubule-stabilizing agent (ab143616)

    Key features and details

    • Microtubule-stabilizing agent
    • CAS Number: 189453-10-9
    • Purity: > 98%
    • Soluble in ethanol to 100 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Epothilone D, Microtubule-stabilizing agent

    • Description

      Microtubule-stabilizing agent

    • Biological description

      Microtubule-stabilizing agent. Epothilone A (ab143615) and B (ab141271) analog. Improves microtubule density and axonal integrity Shows antineoplastic and neuroprotective effects in vivo. Blood-brain barrier permeable.

    • Purity

      > 98%

    • CAS Number

      189453-10-9

    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione

    • Molecular weight

      491.68

    • Molecular formula

      C27H41NO5S

    • PubChem identifier

      447865

    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

    • Solubility overview

      Soluble in ethanol to 100 mM and in DMSO to 100 mM

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC1CCCC(=CCC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC2=CSC(=N2)C)C)C

    • Source

      Synthetic

    • Research areas

    Images

    • Chemical Structure - Epothilone D, Microtubule-stabilizing agent (ab143616)
      Chemical Structure - Epothilone D, Microtubule-stabilizing agent (ab143616)
      2D chemical structure image of ab143616, Epothilone D, Microtubule-stabilizing agent

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    References (3)

    Publishing research using ab143616? Please let us know so that we can cite the reference in this datasheet.

    ab143616 has been referenced in 3 publications.

    • Clark JA  et al. Epothilone D alters normal growth, viability and microtubule dependent intracellular functions of cortical neurons in vitro. Sci Rep 10:918 (2020). PubMed: 31969604
    • Xiong TQ  et al. The effects of epothilone D on microtubule degradation and delayed neuronal death in the hippocampus following transient global ischemia. J Chem Neuroanat 98:17-26 (2019). PubMed: 30872184
    • Sandner B  et al. Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats. Exp Neurol 306:250-259 (2018). PubMed: 29408734

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