Overview

  • Product name
    Epoxomicin, 20S proteasome inhibitor
  • Description
    Potent, selective, irreversible and cell-permeable 20S proteasome inhibitor
  • Biological description
    Potent, selective, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 4 nM). Predominantly inhibits the chymotrypsin-like activity. Anti-inflammatory and antitumor agent. Active in vitro and in vivo.
  • Purity
    > 97%
  • CAS Number
    134381-21-8
  • Chemical structure
    Chemical Structure

Properties

References

This product has been referenced in:
  • Meng L  et al. Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci U S A 96:10403-8 (1999). Read more (PubMed: 10468620) »
  • Kim KB  et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett 9:3335-40 (1999). Read more (PubMed: 10612595) »
  • Hanada M  et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo) 45:1746-52 (1992). Read more (PubMed: 1468981) »

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