Overview

  • Product name

  • Description

    Rabbit polyclonal to EPS15R
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human EPS15R aa 585-864.
    Database link: Q9UBC2

  • Positive control

    • IHC-P: Human skin and pancreatic tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab235365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
  • Sequence similarities

    Contains 1 EF-hand domain.
    Contains 3 EH domains.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues by EGFR.
  • Cellular localization

    Cell membrane. Nucleus. Membrane > coated pit. Localized to plasma membrane coated pits.
  • Information by UniProt
  • Database links

  • Alternative names

    • EP15R_HUMAN antibody
    • epidermal growth factor receptor pathway substrate 15- ike 1 antibody
    • Epidermal growth factor receptor substrate 15 like 1 antibody
    • Epidermal growth factor receptor substrate 15-like 1 antibody
    • epidermal growth factor receptor substrate EPS15R antibody
    • Eps15 related protein antibody
    • Eps15-related protein antibody
    • EPS15L1 antibody
    • Eps15R antibody
    see all

Images

  • Paraffin-embedded human skin tissue stained for EPS15R using ab235365 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human pancreatic tissue stained for EPS15R using ab235365 at 1/100 dilution in immunohistochemical analysis.

References

ab235365 has not yet been referenced specifically in any publications.

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