Overview

  • Product name

    Anti-EPX antibody [EPO104]
    See all EPX primary antibodies
  • Description

    Mouse monoclonal [EPO104] to EPX
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Fr, Flow Cyt, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to Human EPX. Human eosinophils from a patient with hypereosinophilic syndrome

  • Positive control

    • Tonsil

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: 99% PBS, 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    purified from Bioreactor Concentrates
  • Clonality

    Monoclonal
  • Clone number

    EPO104
  • Isotype

    IgG1
  • Light chain type

    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab199005 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr Use a concentration of 0.5 - 1 µg/ml.

30 mins room temperature

Flow Cyt Use 0.5-1µg for 106 cells.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

ICC/IF Use a concentration of 0.5 - 1 µg/ml.

Target

  • Function

    Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
  • Involvement in disease

    Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining.
  • Sequence similarities

    Belongs to the peroxidase family. XPO subfamily.
  • Cellular localization

    Cytoplasmic granule. Cytoplasmic granules of eosinophils.
  • Information by UniProt
  • Database links

  • Alternative names

    • Eosinophil peroxidase [Precursor] antibody
    • Eosinophil peroxidase antibody
    • Eosinophil peroxidase heavy chain antibody
    • EPER antibody
    • EPO antibody
    • EPP antibody
    • EPX antibody
    • EPX PEN antibody
    • PERE antibody
    • PERE_HUMAN antibody
    see all

References

ab199005 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab199005.
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