Overview

  • Product name

  • Description

    Rabbit polyclonal to ER81/ETV1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human ER81/ETV1 (N terminal).

  • Positive control

    • HT29 cell lysate.
  • General notes

     This product was previously labelled as ER81

     

Properties

Applications

Our Abpromise guarantee covers the use of ab136121 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 55 kDa.

Target

  • Function

    Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
  • Tissue specificity

    Very highly expressed in brain, highly expressed in testis, lung and heart, moderately in spleen, small intestine, pancreas and colon, weakly in liver, prostate and thymus, very weakly in skeletal muscle, kidney and ovary and not in placenta and peripheral blood leukocytes.
  • Involvement in disease

    Defects in ETV1 are a cause of Ewing sarcoma (ES) [MIM:612219]. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. Note=A chromosomal aberration involving ETV1 is found in patients with Erwing sarcoma. Translocation t(7;22)(p22;q12) with EWSR1.
  • Sequence similarities

    Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
  • Post-translational
    modifications

    Sumoylated.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp781L0674 antibody
    • ER81 antibody
    • ER81 protein antibody
    • ER81, mouse, homolog of antibody
    • ETS translocation variant 1 antibody
    • ets variant gene 1 antibody
    • Ets-related protein 81 antibody
    • Etsrp81 antibody
    • ETV 1 antibody
    • ETV1 antibody
    • ETV1_HUMAN antibody
    • MGC104699 antibody
    • MGC120533 antibody
    • MGC120534 antibody
    see all

Images

  • Anti-ER81/ETV1 antibody (ab136121) at 1/500 dilution + HT29 cell lysate at 30 µg

    Predicted band size: 55 kDa

References

ab136121 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab136121.
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