Overview

  • Product name

  • Description

    Rabbit polyclonal to ERAB
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human ERAB (internal sequence). The exact sequence is proprietary.
    Database link: Q99714

  • Positive control

    • WB: HeLa and HepG2 whole cell lysates. IHC-P: Human colon carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab228863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 27 kDa.

Target

  • Function

    Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
  • Tissue specificity

    Expressed in normal tissues but is overexpressed in neurons affected in AD.
  • Involvement in disease

    Defects in HSD17B10 are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD deficiency) [MIM:300438]. MHBD deficiency leads to neurological abnormalities, including psychomotor retardation, and, in virtually all patients, loss of mental and motor skills.
    Defects in HSD17B10 are the cause of mental retardation syndromic X-linked type 10 (MRXS10) [MIM:300220]. MRXS10 is characterized by mild mental retardation, choreoathetosis and abnormal behavior.
    A chromosomal microduplication involving HSD17B10 and HUWE1 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.
  • Sequence similarities

    Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Cellular localization

    Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • 17 beta hydroxysteroid dehydrogenase 10 antibody
    • 17 beta hydroxysteroid dehydrogenase type 10 antibody
    • 17-beta-HSD 10 antibody
    • 17-beta-hydroxysteroid dehydrogenase 10 antibody
    • 17b HSD10 antibody
    • 3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody
    • 3 hydroxyacyl CoA dehydrogenase type 2 antibody
    • 3 hydroxyacyl CoA dehydrogenase type II antibody
    • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody
    • 3-hydroxyacyl-CoA dehydrogenase type II antibody
    • 3-hydroxyacyl-CoA dehydrogenase type-2 antibody
    • AB binding alcohol dehydrogenase antibody
    • ABAD antibody
    • Ads9 antibody
    • Amyloid beta binding polypeptide antibody
    • Amyloid beta peptide binding alcohol dehydrogenase antibody
    • Amyloid beta peptide binding protein antibody
    • Amyloid beta peptide binding protein antibody
    • CAMR antibody
    • DUPXp11.22 antibody
    • Endoplasmic Reticulum Amyloid Binding Protein antibody
    • Endoplasmic reticulum associated amyloid beta peptide binding protein antibody
    • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody
    • ER associated amyloid beta-binding protein antibody
    • ERAB antibody
    • HADH 2 antibody
    • HADH2 antibody
    • HCD 2 antibody
    • HCD2 antibody
    • HCD2_HUMAN antibody
    • Hsd17b10 antibody
    • Hydroxyacyl CoA Dehydrogenase type II antibody
    • Hydroxyacyl Coenzyme A dehydrogenase type II antibody
    • Hydroxysteroid (17 beta) dehydrogenase 10 antibody
    • Mental retardation X linked syndromic 11 antibody
    • MHBD antibody
    • Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody
    • Mitochondrial ribonuclease P protein 2 antibody
    • Mitochondrial RNase P protein 2 antibody
    • MRPP2 antibody
    • MRX17 antibody
    • SCHAD antibody
    • SDR5C1 antibody
    • Short chain dehydrogenase/reductase family 5C member 1 antibody
    • Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody
    • Short chain type dehydrogenase/reductase XH98G2 antibody
    • Short-chain type dehydrogenase/reductase XH98G2 antibody
    • Type 10 17b HSD antibody
    • Type 10 17beta hydroxysteroid dehydrogenase antibody
    • Type II HADH antibody
    • XH98G2 antibody
    see all

Images

  • All lanes : Anti-ERAB antibody (ab228863) at 1/1000 dilution

    Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
    Lane 2 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 27 kDa



    12% SDS-PAGE gel.

  • Paraffin-embedded human colon carcinoma tissue stained for ERAB using ab228863 at 1/250 dilution in immunohistochemical analysis.

References

ab228863 has not yet been referenced specifically in any publications.

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