Overview

  • Product name

  • Description

    Goat polyclonal to Erbin
  • Host species

    Goat
  • Tested applications

    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide from C terminal amino acids of Human Erbin.

  • Positive control

    • Human Colon tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab124653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/32000.
IHC-P Use a concentration of 3.75 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state.
  • Tissue specificity

    Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
  • Sequence similarities

    Belongs to the LAP (LRR and PDZ) protein family.
    Contains 17 LRR (leucine-rich) repeats.
    Contains 1 PDZ (DHR) domain.
  • Cellular localization

    Cell junction > hemidesmosome. Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Densin-180-like protein antibody
    • Erbb2-interacting protein antibody
    • Erbb2ip antibody
    • Erbin antibody
    • LAP2 antibody
    • LAP2_HUMAN antibody
    • Protein LAP2 antibody
    see all

Images

  • ab124653, at 3.75 µg/ml, staining Erbin in Human Colon (epithelium) tissue by Immunohistochemistry.

References

ab124653 has not yet been referenced specifically in any publications.

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