Anti-EREG antibody [MM0265- 12Y4] (ab89291)
Key features and details
- Mouse monoclonal [MM0265- 12Y4] to EREG
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-EREG antibody [MM0265- 12Y4]
See all EREG primary antibodies -
Description
Mouse monoclonal [MM0265- 12Y4] to EREG -
Host species
Mouse -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length Human EREG protein.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography. -
Clonality
Monoclonal -
Clone number
MM0265- 12Y4 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab89291 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration.
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Notes |
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WB
Use at an assay dependent concentration. |
Target
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Function
May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. -
Tissue specificity
In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. -
Sequence similarities
Contains 1 EGF-like domain. -
Cellular localization
Cell membrane and Secreted > extracellular space. - Information by UniProt
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Database links
- Entrez Gene: 2069 Human
- Omim: 602061 Human
- SwissProt: O14944 Human
- Unigene: 115263 Human
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Alternative names
- Epiregulin antibody
- EPR antibody
- ER antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab89291 has been referenced in 1 publication.
- Oliveras-Ferraros C et al. Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells. Br J Cancer 106:1406-14 (2012). PubMed: 22491422