Overview

  • Product name

    Esculetin, lipoxygenase inhibitor
  • Description

    Potent, selective and non-competitive lipoxygenase inhibitor
  • Biological description

    Potent, selective and non-competitive lipoxygenase inhibitor (IC50 = 650 nM). Inhibits cell proliferation in tumor cells in vitro (IC50 = 193 μM). Suppresses MMP-9 expression in vitro. Antioxidant and antitumor agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    305-01-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jiménez-Orozco FA  et al. Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. Eur J Pharmacol 668:35-41 (2011). Read more (PubMed: 21741969) »
  • Sekiya K  et al. Selective inhibition of platelet lipoxygenase by esculetin. Biochim Biophys Acta 713:68-72 (1982). Read more (PubMed: 6814494) »
  • Lee SJ  et al. Inhibitory effect of esculetin on migration, invasion and matrix metalloproteinase-9 expression in TNF-a-induced vascular smooth muscle cells. Mol Med Rep 4:337-41 (0). Read more (PubMed: 21468574) »

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