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    ese1-antibody-ab194943.pdf

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Epigenetics and Nuclear Signaling Transcription Other factors
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Anti-ESE1 antibody (ab194943)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESE1 antibody (ab194943)

    Key features and details

    • Rabbit polyclonal to ESE1
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human ESE1 protein (ab114718)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-ESE1 antibody
      See all ESE1 primary antibodies
    • Description

      Rabbit polyclonal to ESE1
    • Host species

      Rabbit
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Dog, Gorilla, Orangutan
    • Immunogen

      This product was produced with the following immunogens:
      Synthetic peptide corresponding to Human ESE1 aa 1-100 (N terminal). NCBI Accession No. NP_004424.3.
      Database link: P78545

      Synthetic peptide corresponding to Human ESE1 aa 350 to the C-terminus (C terminal). NCBI Accession No. NP_004424.3.
      Database link: P78545

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Recombinant Human ESE1 protein (ab131849) can be used as a positive control in WB. Human breast tissue.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservative: 0.02% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Epigenetics and Nuclear Signaling
      • Transcription
      • Other factors

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human ESE1 protein (ab114718)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab194943 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 5 µg/ml.
    Notes
    IHC-P
    Use a concentration of 5 µg/ml.

    Target

    • Function

      Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
    • Tissue specificity

      Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
    • Sequence similarities

      Belongs to the ETS family.
      Contains 1 ETS DNA-binding domain.
      Contains 1 PNT (pointed) domain.
    • Domain

      the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
    • Cellular localization

      Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
    • Target information above from: UniProt accession P78545 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 421177 Chicken
      • Entrez Gene: 508503 Cow
      • Entrez Gene: 490235 Dog
      • Entrez Gene: 101127911 Gorilla
      • Entrez Gene: 100146645 Horse
      • Entrez Gene: 1999 Human
      • Entrez Gene: 13710 Mouse
      • Entrez Gene: 100174422 Orangutan
      • Entrez Gene: 100357597 Rabbit
      • Entrez Gene: 304815 Rat
      • Omim: 602191 Human
      • SwissProt: P78545 Human
      • SwissProt: Q3UPW2 Mouse
      • SwissProt: Q4V7E1 Rat
      • Unigene: 67928 Human
      • Unigene: 441439 Mouse
      • Unigene: 3063 Rat
      see all
    • Alternative names

      • E74 like factor 3 antibody
      • E74 like factor 3 ets domain transcription factor antibody
      • E74 like factor 3 ets domain transcription factor epithelial specific antibody
      • E74 like factor 3 ETS domain transcription factor serine box epithelial specific antibody
      • E74-like factor 3 antibody
      • Elf3 antibody
      • ELF3_HUMAN antibody
      • Epithelial restricted with serine box antibody
      • Epithelial-restricted with serine box antibody
      • Epithelium restricted Ets protein ESX antibody
      • Epithelium specific Ets factor 1 antibody
      • Epithelium specific Ets transcription factor 1 antibody
      • Epithelium-restricted Ets protein ESX antibody
      • Epithelium-specific Ets transcription factor 1 antibody
      • EPR 1 antibody
      • EPR1 antibody
      • ERT antibody
      • ESE-1 antibody
      • ESX antibody
      • Ets domain transcription factor serine box antibody
      • Ets domain transcription factor serine box epithelial specific antibody
      • Ets transcription factor antibody
      • ETS-related transcription factor Elf-3 antibody
      • jen antibody
      • MGC139318 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESE1 antibody (ab194943)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESE1 antibody (ab194943)

      Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast tissue, labeling ESE1 using ab194943 at 5 µg/mL.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab194943? Please let us know so that we can cite the reference in this datasheet.

    ab194943 has not yet been referenced specifically in any publications.

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