Anti-ESE1 antibody (ab194943)

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Overview

  • Product name

    Anti-ESE1 antibody
    See all ESE1 primary antibodies

  • Description

    Rabbit polyclonal to ESE1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WB, IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Dog, Gorilla, Orangutan

  • Immunogen

    This product was produced with the following immunogens:
    Synthetic peptide corresponding to Human ESE1 aa 1-16 (N terminal). NCBI Accession No. NP_004424.3.
    Sequence:

    MAATCEISNIFSNYFS


    Database link: P78545

    Synthetic peptide corresponding to Human ESE1 aa 358-371 (C terminal). NCBI Accession No. NP_004424.3.
    Sequence: SSGWKEEEVLQSRN
    Database link: P78545

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • Positive control

    • Recombinant Human ESE1 protein (ab131849) can be used as a positive control in WB. Human breast tissue.

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...

  • Purity

    Immunogen affinity purified

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Research areas

Applications

Our Abpromise guarantee covers the use of ab194943 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 41 kDa.
IHC-P Use a concentration of 5 µg/ml.

Target

  • Function

    Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

  • Tissue specificity

    Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.

  • Sequence similarities

    Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
    Contains 1 PNT (pointed) domain.

  • Domain

    the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

  • Cellular localization

    Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • E74 like factor 3 antibody
    • E74 like factor 3 ets domain transcription factor antibody
    • E74 like factor 3 ets domain transcription factor epithelial specific antibody
    • E74 like factor 3 ETS domain transcription factor serine box epithelial specific antibody
    • E74-like factor 3 antibody
    • Elf3 antibody
    • ELF3_HUMAN antibody
    • Epithelial restricted with serine box antibody
    • Epithelial-restricted with serine box antibody
    • Epithelium restricted Ets protein ESX antibody
    • Epithelium specific Ets factor 1 antibody
    • Epithelium specific Ets transcription factor 1 antibody
    • Epithelium-restricted Ets protein ESX antibody
    • Epithelium-specific Ets transcription factor 1 antibody
    • EPR 1 antibody
    • EPR1 antibody
    • ERT antibody
    • ESE-1 antibody
    • ESX antibody
    • Ets domain transcription factor serine box antibody
    • Ets domain transcription factor serine box epithelial specific antibody
    • Ets transcription factor antibody
    • ETS-related transcription factor Elf-3 antibody
    • jen antibody
    • MGC139318 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESE1 antibody (ab194943)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESE1 antibody (ab194943)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast tissue, labeling ESE1 using ab194943 at 5 µg/mL.

References

ab194943 has not yet been referenced specifically in any publications.

Publishing research using ab194943? Please let us know so that we can cite the reference in this datasheet.

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