Anti-ESM1 antibody (ab103590)
Key features and details
- Rabbit polyclonal to ESM1
- Suitable for: WB, ICC/IF
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-ESM1 antibody
See all ESM1 primary antibodies -
Description
Rabbit polyclonal to ESM1 -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IFmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant full length protein within Human ESM1 aa 1-200. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab103590 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/1000. Predicted molecular weight: 20 kDa.
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ICC/IF | (2) |
Use at an assay dependent concentration.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 20 kDa. |
ICC/IF
Use at an assay dependent concentration. |
Target
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Function
May have potent implications in lung endothelial cell-leukocyte interactions. -
Tissue specificity
Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney. -
Sequence similarities
Contains 1 IGFBP N-terminal domain. -
Post-translational
modificationsMay contain intrachain disulfide bonds. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 11082 Human
- Entrez Gene: 71690 Mouse
- Omim: 601521 Human
- SwissProt: Q9NQ30 Human
- SwissProt: Q9QYY7 Mouse
- Unigene: 129944 Human
- Unigene: 38929 Mouse
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Alternative names
- Endocan antibody
- Endothelial cell specific molecule 1 antibody
- Endothelial cell-specific molecule 1 antibody
see all
Images
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Anti-ESM1 antibody (ab103590) at 1/500 dilution + Human kidney tissue lysate at 50 µg
Predicted band size: 20 kDa -
All lanes : Anti-ESM1 antibody (ab103590) at 1/500 dilution
Lane 1 : ESM1 transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 20 kDa
Protocols
Datasheets and documents
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Datasheet download
References (14)
ab103590 has been referenced in 14 publications.
- Li YK et al. Validation of ESM1 Related to Ovarian Cancer and the Biological Function and Prognostic Significance. Int J Biol Sci 19:258-280 (2023). PubMed: 36594088
- Gu X et al. ESM1/HIF‑1α pathway modulates chronic intermittent hypoxia‑induced non‑small‑cell lung cancer proliferation, stemness and epithelial‑mesenchymal transition. Oncol Rep 45:1226-1234 (2021). PubMed: 33650648
- Choi HS et al. Anticancer Effect of Benzimidazole Derivatives, Especially Mebendazole, on Triple-Negative Breast Cancer (TNBC) and Radiotherapy-Resistant TNBC In Vivo and In Vitro. Molecules 26:N/A (2021). PubMed: 34500557
- Jin H & Kim HJ NK Cells Lose Their Cytotoxicity Function against Cancer Stem Cell-Rich Radiotherapy-Resistant Breast Cancer Cell Populations. Int J Mol Sci 22:N/A (2021). PubMed: 34502547
- Suzuki K et al. Recombinant Thrombomodulin Protects Against Lipopolysaccharide-induced Acute Respiratory Distress Syndrome Via Preservation of Pulmonary Endothelial Glycocalyx. Br J Pharmacol N/A:N/A (2020). PubMed: 32497259