Overview

  • Product name

    Esmolol, beta1 receptor antagonist
  • Description

    Short-acting cardioselective β1 receptor antagonist. Antiarrhythmic agent.
  • Alternative names

    • Beta 1 receptor antagonist
  • Biological description

    Short-acting cardioselective β1 receptor antagonist. Antiarrhythmic agent. Reversibly inhibits Na+ inward currents (IC50 = 74 μM). Shows antihypertensive effects in vivo. Orally active.

  • Purity

    > 98%
  • CAS Number

    81147-92-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Methyl 3-[4-(2-hydroxy-3-propan-2-ylamino-propoxy)phenyl]propanoate
  • Molecular weight

    295.37
  • Molecular formula

    C16H25NO4
  • PubChem identifier

    59768
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Arnalich-Montiel A  et al. Short-term esmolol improves coronary artery remodeling in spontaneously hypertensive rats through increased nitric oxide bioavailability and superoxide dismutase activity. Biomed Res Int 2014:531087 (2014). Read more (PubMed: 24795884) »
  • Zhang Q & Li C Combination of epinephrine with esmolol attenuates post-resuscitation myocardial dysfunction in a porcine model of cardiac arrest. PLoS One 8:e82677 (2013). Read more (PubMed: 24367539) »
  • Deng CY  et al. Esmolol inhibits Na+ current in rat ventricular myocytes. Methods Find Exp Clin Pharmacol 28:697-702 (2006). Read more (PubMed: 17235414) »
See 1 Publication for this product

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