Estradiol benzoate, Estradiol analog (ab145743)

Overview

  • Product name

    Estradiol benzoate, Estradiol analog
  • Description

    Estradiol analog which binds to the human, murine and chicken ERα with IC50 of 22-28 nM.
  • Alternative names

    • Agofollin
    • Diffolisterol
    • E2 Benzoate
    • EB
    • ODB
    • Oestradiol benzoate
    • Progynon-B
    see all
  • Biological description

    Estradiol analog which contains a benzyl ester at the C-3 position. Binds to the human and murine estrogen receptor α (ERα), and chicken ER with IC50 values in the range of 22-28 nM. This reflects a 6-10 fold reduction in binding affinity compared to estradiol. Used in combination with a progestin to induce estrus in domestic livestock.

  • Purity

    > 97%
  • CAS Number

    50-50-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(8R,9S,13S,14S,17S)-17-Hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate
  • Molecular weight

    376.49
  • Molecular formula

    C25H28O3
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Lei X  et al. Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway. Reprod Domest Anim 51:75-84 (2016). Read more (PubMed: 26684898) »
  • Cavalieri J  et al. Ovarian follicular development in Holstein cows following synchronisation of oestrus with oestradiol benzoate and an intravaginal progesterone releasing insert for 5-9 days and duration of the oestrous cycle and concentrations of progesterone following ovulation. Anim Reprod Sci 81:177-93 (2004). Read more (PubMed: 14998646) »
  • Matthews J  et al. Differential estrogen receptor binding of estrogenic substances: a species comparison. J Steroid Biochem Mol Biol 74:223-34 (2000). Read more (PubMed: 11162928) »
  • Oriowo MA  et al. A comparison of the pharmacokinetic properties of three estradiol esters. Contraception 21:415-24 (1980). Read more (PubMed: 7389356) »

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