Overview

  • Product name

    Estramustine, Microtubule assembly inhibitor
  • Description

    Microtubule assembly inhibitor. Antiproliferative and induces DNA strand breaks.
  • Biological description

    Microtubule assembly inhibitor. Inhibits endothelial cell proliferation (IC50 = 4.5 μM) and down-regulates prostate-specific antigen expression (IC50 = 10.97 μM). Alkylating and antitumor agent. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    2998-57-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl]N,N-bis(2-chloroethyl)carbamate
  • Molecular weight

    440.40
  • Molecular formula

    C23H31Cl2NO3
  • PubChem identifier

    259331
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lam T  et al. Metronomic chemotherapy dosing-schedules with estramustine and temozolomide act synergistically with anti-VEGFR-2 antibody to cause inhibition of human umbilical venous endothelial cell growth. Acta Oncol 46:1169-77 (2007). Read more (PubMed: 17851838) »
  • Wang LG  et al. Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptor. Biochem Pharmacol 55:1427-33 (1998). Read more (PubMed: 10076535) »
  • von Schoultz E  et al. Effects of estramustine on DNA and cell membrane in malignant glioma cells. Acta Oncol 30:719-23 (1991). Read more (PubMed: 1958392) »

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