Estramustine phosphate sodium, antimitotic, antitumour agent (ab142747)

Overview

  • Product name

    Estramustine phosphate sodium, antimitotic, antitumour agent
  • Description

    Antimitotic, antitumour agent
  • Biological description

    Antimitotic, antitumour agent. Nor-nitrogen mustard conjugate of estradiol (Asc 657). Selective for prostate cells. Interferes with microtubule dynamics and reduces plasma levels of testosterone. Shows antineoplastic effects in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    52205-73-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Disodium [3-[bis(2-chloroethyl)carbamoyloxy]-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] phosphate
  • Molecular weight

    564.35
  • Molecular formula

    C23H30Cl2NNa2O6P
  • PubChem identifier

    53395146
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12CCC3C(C1CCC2OP(=O)([O-])[O-])CCC4=C3C=CC(=C4)OC(=O)N(CCCl)CCCl.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Mack JT  et al. Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies. Biomed Pharmacother 66:403-8 (2012). Read more (PubMed: 22898081) »
  • Higashioka M  et al. [Effect of the 5-HT3 receptor antagonist granisetron on estramustine phosphate sodium (Estracyt)-induced emesis in ferrets]. Hinyokika Kiyo 56:361-5 (2010). Read more (PubMed: 20724808) »
  • Ståhlberg K  et al. Distribution of radioiodinated estramustine binding protein antibody in mice with DU-145 prostate cancer xenograft. Anticancer Res 27:2275-8 (0). Read more (PubMed: 17695514) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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