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Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger
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Anti-Estrogen Related Receptor alpha antibody (ab150560)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Related Receptor alpha antibody (ab150560)

    Key features and details

    • Rabbit polyclonal to Estrogen Related Receptor alpha
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human Estrogen Related Receptor alpha protein (ab152370)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-Estrogen Related Receptor alpha antibody
      See all Estrogen Related Receptor alpha primary antibodies
    • Description

      Rabbit polyclonal to Estrogen Related Receptor alpha
    • Host species

      Rabbit
    • Specificity

      BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except Estrogen Related Receptor gamma (60%).
    • Tested Applications & Species

      Application Species
      IHC-P
      Human
      See all applications and species data
    • Immunogen

      Synthetic peptide corresponding to Human Estrogen Related Receptor alpha. Synthetic peptide, corresponding to 15 amino acids from ligand-binding domain of Human Estrogen Related Receptor alpha.
      Database link: P11474

    • Positive control

      • Human breast carcinoma tissue.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C.
    • Storage buffer

      Preservative: 0.1% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Epigenetics and Nuclear Signaling
      • Transcription
      • Domain Families
      • Zinc Finger
      • Signal Transduction
      • Signaling Pathway
      • Nuclear Signaling
      • Nuclear Hormone Receptors
      • Estrogen
      • Epigenetics and Nuclear Signaling
      • Nuclear Signaling Pathways
      • Nuclear Receptors
      • Estrogen
      • Cancer
      • Signal transduction
      • Nuclear signaling
      • Nuclear hormone receptors
      • Estrogen
      • Metabolism
      • Pathways and Processes
      • Mitochondrial Metabolism
      • Mitochondrial Biogenesis
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Nucleotide metabolism
      • Molecular processes
      • Mitochondrial transcription

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human Estrogen Related Receptor alpha protein (ab152370)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab150560 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    IHC-P
    Human
    All applications
    Mouse
    Rat
    Horse
    Hamster
    Cow
    Dog
    Pig
    Monkey
    Gorilla
    Application Abreviews Notes
    IHC-P
    Use a concentration of 11 - 21 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 11 - 21 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Function

      Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.
    • Sequence similarities

      Belongs to the nuclear hormone receptor family. NR3 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Post-translational
      modifications

      Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.
      Sumoylated by SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activiy, but has no effect on subcellular location nor on DNA binding.
    • Cellular localization

      Nucleus.
    • Target information above from: UniProt accession P11474 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 507834 Cow
      • Entrez Gene: 403169 Dog
      • Entrez Gene: 2101 Human
      • Entrez Gene: 26379 Mouse
      • Entrez Gene: 100322868 Pig
      • Entrez Gene: 293701 Rat
      • Omim: 601998 Human
      • SwissProt: Q6QMY5 Dog
      • SwissProt: P11474 Human
      • SwissProt: O08580 Mouse
      • SwissProt: Q5QJV7 Rat
      • Unigene: 110849 Human
      • Unigene: 386776 Mouse
      • Unigene: 130171 Rat
      see all
    • Alternative names

      • Err 1 antibody
      • ERR a antibody
      • ERR alpha antibody
      • ERR-alpha antibody
      • Err1 antibody
      • ERR1 protein antibody
      • ERR1_HUMAN antibody
      • ERRa antibody
      • ERRalpha antibody
      • ESRL 1 antibody
      • ESRL1 antibody
      • ESRR A antibody
      • Esrra antibody
      • Estrogen receptor like 1 antibody
      • Estrogen receptor related 1 antibody
      • estrogen receptor related receptor alpha antibody
      • Estrogen receptor-like 1 antibody
      • Estrogen related receptor alpha antibody
      • Estrogen-related receptor alpha antibody
      • Estrra antibody
      • hERR1 antibody
      • NR3B1 antibody
      • Nuclear receptor subfamily 3 group B member 1 antibody
      • Steroid hormone receptor ERR1 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Related Receptor alpha antibody (ab150560)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Estrogen Related Receptor alpha antibody (ab150560)
      Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human breast carcinoma tissue, labeling Estrogen Related Receptor alpha using ab150560 at 21 µg/ml.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab150560? Please let us know so that we can cite the reference in this datasheet.

    ab150560 has not yet been referenced specifically in any publications.

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