Overview

  • Product name

    Anti-Estrogen Related Receptor gamma antibody [EPR8100]
    See all Estrogen Related Receptor gamma primary antibodies
  • Description

    Rabbit monoclonal [EPR8100] to Estrogen Related Receptor gamma
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human Estrogen Related Receptor gamma (P62508)

  • Positive control

    • Human ovary cancer, breast, fetal heart or spleen lysate
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab128930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 51 kDa.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function

      Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
    • Tissue specificity

      Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
    • Sequence similarities

      Belongs to the nuclear hormone receptor family. NR3 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Developmental stage

      Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.
    • Post-translational
      modifications

      Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity.
      Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.
    • Cellular localization

      Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • DKFZp781L1617 antibody
      • ERR 3 antibody
      • ERR G2 antibody
      • ERR gamma 2 antibody
      • ERR gamma-2 antibody
      • ERR3 antibody
      • ERR3_HUMAN antibody
      • ERRG 2 antibody
      • ERRG2 antibody
      • ERRgamma antibody
      • ESRRG antibody
      • Estrogen receptor related protein 3 antibody
      • Estrogen receptor-related protein 3 antibody
      • Estrogen-related receptor gamma antibody
      • FLJ16023 antibody
      • KIAA0832 antibody
      • NR3B3 antibody
      • Nuclear receptor subfamily 3 group B member 3 antibody
      see all

    Images

    • All lanes : Anti-Estrogen Related Receptor gamma antibody [EPR8100] (ab128930) at 1/1000 dilution

      Lane 1 : Human ovary cancer lysate
      Lane 2 : Human breast lysate
      Lane 3 : Human fetal heart lysate
      Lane 4 : Human spleen lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat

      anti-rabbit at 1/2000 dilution

      Predicted band size: 51 kDa

    References

    This product has been referenced in:

    • Frattini V  et al. A metabolic function of FGFR3-TACC3 gene fusions in cancer. Nature 553:222-227 (2018). Read more (PubMed: 29323298) »
    • Popov DV  et al. Effect of aerobic training on baseline expression of signaling and respiratory proteins in human skeletal muscle. Physiol Rep 6:e13868 (2018). Read more (PubMed: 30198217) »
    See all 3 Publications for this product

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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