Human Predicted to work with:
Mouse, Rat, Rabbit, Horse, Chicken, Hamster, Cow, Dog, Turkey, Xenopus laevis, Lizard, Monkey, Zebrafish, Gorilla, Opossum, Common marmoset, Orangutan, Bat, Platypus, Elephant
Synthetic 14 amino acid peptide from the N terminus of Human Estrogen Related Receptor gamma.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland.
Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver.
Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity. Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity.