Overview

  • Product name

  • Description

    Rabbit polyclonal to ETL
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Dog, Turkey, Pig, Xenopus laevis, Monkey, Gorilla, Bat
  • Immunogen

    Synthetic peptide corresponding to 19 amino acids from the C-terminus of Human ETL (Q9HBW9).

  • Positive control

    • Human heart tissue

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab150489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 - 11 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Could be involved in cardiac development.
  • Tissue specificity

    Mainly expressed in smooth muscle.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 2 EGF-like domains.
    Contains 1 GPS domain.
  • Developmental stage

    Up-regulated in the adult heart.
  • Domain

    The transmembrane domain is not required for cleavage, but it is required for dimer formation.
  • Post-translational
    modifications

    Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • ADGRL4 antibody
    • Adhesion G protein-coupled receptor L4 antibody
    • EGF antibody
    • EGF latrophilin and seven transmembrane domain containing 1 antibody
    • EGF TM7 latrophilin related protein antibody
    • EGF, latrophilin and seven transmembrane domain-containing protein 1 antibody
    • EGF, latrophilin, and 7 transmembrane domain-containing protein 1 antibody
    • EGF-, TM7-, and latrophilin-related protein antibody
    • EGF-TM7-latrophilin-related protein antibody
    • EGFTM7 latrophilin related protein antibody
    • ELTD 1 antibody
    • ELTD1 antibody
    • ELTD1_HUMAN antibody
    • ETL antibody
    • ETL protein antibody
    • KPG_003 antibody
    • latrophilin and seven transmembrane domain-containing protein 1 antibody
    • UNQ202/PRO228 antibody
    • zgc:63629 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded Human heart tissue labelling ETL with ab150489 antibody at a concentration of 11 µg/ml.

References

This product has been referenced in:

  • Ziegler J  et al. Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment. Am J Nucl Med Mol Imaging 9:93-109 (2019). Read more (PubMed: 30911439) »
  • Ziegler J  et al. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol N/A:N/A (2016). Read more (PubMed: 27416955) »
See all 2 Publications for this product

Customer reviews and Q&As

Application
Immunohistochemistry (PFA perfusion fixed frozen sections)
Sample
Mouse Tissue sections (brain with GL261 tumor)
Antigen retrieval step
None
Specification
brain with GL261 tumor
Blocking step
Serum as blocking agent for 2 hour(s) and 0 minute(s) · Concentration: 5 · Temperature: 22°C
Fixative
Paraformaldehyde

Mrs. Francoise Geffroy

Verified customer

Submitted Aug 05 2019

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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