Etoposide phosphate, Topoisomerase II inhibitor (ab142426)

Overview

  • Product name

    Etoposide phosphate, Topoisomerase II inhibitor
  • Description

    Topoisomerase II inhibitor
  • Biological description

    Topoisomerase II inhibitor. Forms ternary complex with DNA and topoisomerase II to prevent re-ligation of DNA strands. Causes errors in DNA synthesis and apoptosis in cancer cells. Increases acetylation of eEF1A. Antitumor agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    117091-64-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kim KY  et al. Membrane-bound alkaline phosphatase gene induces antitumor effect by G2/M arrest in etoposide phosphate-treated cancer cells. Mol Cell Biochem 252:213-21 (2003). Read more (PubMed: 14577595) »
  • Hande KR Etoposide: four decades of development of a topoisomerase II inhibitor. Eur J Cancer 34:1514-21 (1998). Read more (PubMed: 9893622) »
  • Hu JL  et al. Etoposide phosphate enhances the acetylation level of translation elongation factor 1A in PLC5 cells. Z Naturforsch C 67:327-30 (0). Read more (PubMed: 22888539) »

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