Etoposide, Topoisomerase II inhibitor (ab120227)
Key features and details
- Topoisomerase II inhibitor
- CAS Number: 33419-42-0
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Etoposide, Topoisomerase II inhibitor -
Description
Topoisomerase II inhibitor -
Biological description
Topoisomerase II inhibitor. Anticancer agent.
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CAS Number
33419-42-0 -
Chemical structure
Properties
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Chemical name
4'-Demethylepipodophyllotoxin-9-(4,6-O-ethylidene-β-D-glucopyranoside) -
Molecular weight
588.56 -
Molecular formula
C29H32O13 -
PubChem identifier
36462 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1cc(cc(OC)c1O)[C@@H]5c2cc7OCOc7cc2[C@@H](O[C@@H]3OC4CO[C@@H](C)O[C@H]4[C@H](O)[C@H]3O)[C@H]6COC(=O)[C@H]56 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Etoposide, Topoisomerase II inhibitor (ab120227)2D chemical structure image of ab120227, Etoposide, Topoisomerase II inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (8)
ab120227 has been referenced in 8 publications.
- Hu Q et al. The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks. Cell Rep 30:1235-1245.e4 (2020). PubMed: 31995761
- Sola M et al. Tau affects P53 function and cell fate during the DNA damage response. Commun Biol 3:245 (2020). PubMed: 32427887
- Sultana S & Bishayi B Etoposide-mediated depletion of peripheral blood monocytes post s.aureus infection attenuates septic arthritis by modulating macrophage-derived factors responsible for inflammatory destruction. Immunol Lett 220:51-62 (2020). PubMed: 32032616
- Hijaze N et al. Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factors. J Leukoc Biol N/A:N/A (2020). PubMed: 33205451
- Lammert CR et al. AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment. Nature 580:647-652 (2020). PubMed: 32350463
- Tian R et al. CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons. Neuron 104:239-255.e12 (2019). PubMed: 31422865
- Ulrich G et al. Phosphorylation of nuclear Tau is modulated by distinct cellular pathways. Sci Rep 8:17702 (2018). PubMed: 30531974
- Saliou B et al. Development and in vitro evaluation of a novel lipid nanocapsule formulation of etoposide. Eur J Pharm Sci 50:172-80 (2013). PubMed: 23831519