Etoposide, Topoisomerase II inhibitor (ab120227)
Key features and details
- Topoisomerase II inhibitor
- CAS Number: 33419-42-0
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Etoposide, Topoisomerase II inhibitor -
Description
Topoisomerase II inhibitor -
Biological description
Topoisomerase II inhibitor. Anticancer agent.
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CAS Number
33419-42-0 -
Chemical structure
Properties
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Chemical name
4'-Demethylepipodophyllotoxin-9-(4,6-O-ethylidene-β-D-glucopyranoside) -
Molecular weight
588.56 -
Molecular formula
C29H32O13 -
PubChem identifier
36462 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COc1cc(cc(OC)c1O)[C@@H]5c2cc7OCOc7cc2[C@@H](O[C@@H]3OC4CO[C@@H](C)O[C@H]4[C@H](O)[C@H]3O)[C@H]6COC(=O)[C@H]56 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (11)
ab120227 has been referenced in 11 publications.
- Melzer M et al. Influence of Rho/ROCK inhibitor Y-27632 on proliferation of equine mesenchymal stromal cells. Front Vet Sci 10:1154987 (2023). PubMed: 37346276
- Islam R et al. Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance. Cell Rep 40:111097 (2022). PubMed: 35858551
- Moretti FA et al. Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy. Sci Rep 11:23221 (2021). PubMed: 34853379
- Hu Q et al. The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks. Cell Rep 30:1235-1245.e4 (2020). PubMed: 31995761
- Sola M et al. Tau affects P53 function and cell fate during the DNA damage response. Commun Biol 3:245 (2020). PubMed: 32427887