Overview

  • Product name

    Etretinate, Retinoid anti-hyperplasia agent
  • Description

    Retinoid anti-hyperplasia agent
  • Biological description

    Retinoid anti-hyperplasia agent. Acitretin (Asc 2984) prodrug. Inhibits DNA synthesis in hyperproliferative keratinocytes. Modulates epidermal differentiation in vivo.
  • Purity

    > 98%
  • CAS Number

    54350-48-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Ethyl (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoate
  • Molecular weight

    354.49
  • Molecular formula

    C23H30O3
  • PubChem identifier

    5282375
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)C=C(C)C=CC=C(C)C=CC1=C(C(=C(C=C1C)OC)C)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Stosic-Grujicic S  et al. Retinoids differentially regulate the progression of autoimmune diabetes in three preclinical models in mice. Mol Immunol 47:79-86 (2009). Read more (PubMed: 19211146) »
  • White SD  et al. Sebaceous adenitis in dogs and results of treatment with isotretinoin and etretinate: 30 cases (1990-1994). J Am Vet Med Assoc 207:197-200 (1995). Read more (PubMed: 7601715) »
  • Eichner R  et al. Effects of topical retinoids on cytoskeletal proteins: implications for retinoid effects on epidermal differentiation. J Invest Dermatol 98:154-61 (1992). Read more (PubMed: 1370674) »
  • Tong PS  et al. Differential effects of retinoids on DNA synthesis in calcium-regulated murine epidermal keratinocyte cultures. J Invest Dermatol 90:861-8 (1988). Read more (PubMed: 3373014) »

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