Overview

  • Product name

    EUK 134, SOD/catalase mimetic
  • Description

    SOD/catalase mimetic
  • Biological description

    SOD/catalase mimetic. Consumes H2O2 with an initial reaction rate of 234 µM/min. Ameliorates nNOSμ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading. Shows neuroprotective and anti-ischemic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    81065-76-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}bis(6-methoxyphenolate)
  • Molecular weight

    416.74
  • Molecular formula

    C18H18ClMnN2O4
  • PubChem identifier

    45489809
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=CC(=C1[O-])C=NCCN=CC2=C(C(=CC=C2)OC)[O-].[Cl-].[Mn+2]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kumar A  et al. The manganese-salen compound EUK-134 and N-acetyl cysteine rescue from zinc- and paraquat-induced toxicity in rat polymorphonuclear leukocytes. Chem Biol Interact 231:18-26 (2015). Read more (PubMed: 25724285) »
  • Lawler JM  et al. EUK-134 ameliorates nNOSµ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading. Am J Physiol Regul Integr Comp Physiol 306:R470-82 (2014). Read more (PubMed: 24477538) »
  • Decraene D  et al. A synthetic superoxide dismutase/catalase mimetic (EUK-134) inhibits membrane-damage-induced activation of mitogen-activated protein kinase pathways and reduces p53 accumulation in ultraviolet B-exposed primary human keratinocytes. J Invest Dermatol 122:484-91 (2004). Read more (PubMed: 15009734) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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