Key features and details
- Potent inhibitor of L-glutamate uptake
- CAS Number: 314-13-6
- Purity: > 95%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameEvans blue, L-glutamate uptake inhibitor
DescriptionPotent inhibitor of L-glutamate uptake
Potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC50 values are 220 and 150 nM, respectively). Binds with high affinity to serum albumin.
Also available in simple stock solutions (ab146727) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name6,6'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid] tetrasodium salt
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120869 has been referenced in 2 publications.
- Liu Y et al. Evidence of Accumulated Endothelial Progenitor Cells in the Lungs of Rats with Pulmonary Arterial Hypertension by 89Zr-oxine PET Imaging. Mol Ther Methods Clin Dev 17:1108-1117 (2020). PubMed: 32490032
- Wu J et al. Genetic stability of a recombinant adenovirus vaccine vector seed library expressing human papillomavirus type 16 E6 and E7 proteins. Exp Ther Med 9:1161-1165 (2015). IF ; Human . PubMed: 25780403