Overview

  • Product name

    Evans blue (mM/ml), L-glutamate uptake inhibitor
  • Description

    Potent inhibitor of L-glutamate uptake. 1 ml water soluble pack.
  • Biological description

    Potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC50 values are 220 and 150 nM, respectively). Binds with high affinity to serum albumin.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity

    > 95%
  • CAS Number

    314-13-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,6'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid] tetrasodium salt
  • Molecular weight

    960.80
  • Molecular formula

    C34H24N6Na4O14S4
  • PubChem identifier

    9566057
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=S(=O)(O[Na])c6cc(c(N)c5c6ccc(/N=N/c1ccc(cc1C)c4ccc(/N=N/c3ccc2c(cc(c(N)c2c3O)S(=O)(=O)O[Na])S(=O)(=O)O[Na])c(C)c4)c5O)S(=O)(=O)O[Na]
  • Source

    Synthetic

  • Research areas

References

ab146727 has not yet been referenced specifically in any publications.

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