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For the second year running, the ESHG Conference will be taking place virtually, with the aim to be one of the best platforms for knowledge exchange in the area of human genetics.
On August 28-31, 2021, participants will have access to over 100 hours of live sessions and even more on-demand content, which will be available to view for 3 months after the conference. In addition, attendees will be able to network with the top companies in the field of genetics. All of this at your fingertips from anywhere in the world!
CRISPR edited Knockout (KO) cell lines are powerful tools to identify key biomarkers and study disease mechanisms, such as the regulation of pathways by the disruption of gene of interest. In this presentation, we highlight how our KO cell lines can be utilised to investigate signaling pathways. Here we present two case studies, firstly focussing on the TRAIL signaling pathway. By selecting a cell line lacking the TRAIL receptor (DR5), we demonstrate how downstream apoptotic signaling can be attenuated. Secondly, we established our A549 KO cells as physiologically relevant models to study interactions between lung cancer cells and T cells. Disruption of immune-based pathways by CRISPR gene editing is a powerful technique to elucidate the contribution of individual proteins in immune checkpoint signalling by cancer cells.