Key features and details
- Cell permeable, TRPV1 agonist
- CAS Number: 518-17-2
- Purity: > 98%
- Soluble in DMSO to 10 mM (with warming)
- Form / State: Solid
- Source: Evodia rutaecarpa
Product nameEvodiamine, TRPV1 agonist
DescriptionCell permeable, TRPV1 agonist
Biological descriptionCell permeable, TRPV1 agonist (Ki = 5.95 μM). Potent cell viability inhibitor in cancer cells (IC50 = 0.57 μM). Causes mitotic arrest and a consequent apoptosis in vitro. Inhibits nitric oxide production. Antitumor and anti-inflammatory agent. Active in vivo and in vitro.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142427 has been referenced in 1 publication.
- Yang W et al. A mediator of phosphorylated Smad2/3, evodiamine, in the reversion of TAF-induced EMT in normal colonic epithelial cells. Invest New Drugs N/A:N/A (2018). PubMed: 30488243