EX-527, SIRT1 Inhibitor (ab141506)
Key features and details
- Selective SIRT1 Inhibitor
- CAS Number: 49843-98-3
- Purity: > 97%
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
EX-527, SIRT1 Inhibitor -
Description
Selective SIRT1 Inhibitor -
Biological description
Selective, cell-permeable SIRT1 Inhibitor. (IC50= 98 nM, 19.6, 48.7 and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Shows no effect at other HDACs or SIRTs. Enhances p53 acetylation in response to DNA damaging agents.
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Purity
> 97% -
CAS Number
49843-98-3 -
Chemical structure
Properties
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Chemical name
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide -
Molecular weight
248.71 -
Molecular formula
C13H13ClN2O -
PubChem identifier
5113032 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NC(=O)C2CCCc1c3cc(Cl)ccc3nc12 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - EX-527, SIRT1 Inhibitor (ab141506)2D chemical structure image of ab141506, EX-527, SIRT1 Inhibitor
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Functional Studies - EX-527, SIRT1 Inhibitor (ab141506)Time course of SIRT1-substrate deacetylation by recombinant SIRT1 in the presence of EX-527.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (6)
ab141506 has been referenced in 6 publications.
- Mao H et al. Fucoxanthin Attenuates Oxidative Damage by Activating the Sirt1/Nrf2/HO-1 Signaling Pathway to Protect the Kidney from Ischemia-Reperfusion Injury. Oxid Med Cell Longev 2022:7444430 (2022). PubMed: 35126819
- Ruan C et al. Neuroprotective effects of metformin on cerebral ischemia-reperfusion injury by regulating PI3K/Akt pathway. Brain Behav 11:e2335 (2021). PubMed: 34473417
- Zhan H et al. Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple Targets. Oxid Med Cell Longev 2021:8889195 (2021). PubMed: 34646427
- Zhang J et al. N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation. J Diabetes Res 2020:1080152 (2020). PubMed: 32280711
- Wu Y et al. Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy. Mol Med Rep 22:2219-2226 (2020). PubMed: 32705226
- Liu SP et al. Secukinumab attenuates reactive astrogliosis via IL-17RA/(C/EBPß)/SIRT1 pathway in a rat model of germinal matrix hemorrhage. CNS Neurosci Ther N/A:N/A (2019). PubMed: 31020769