EX-527, SIRT1 Inhibitor (ab141506)
- Datasheet
- References (1)
Overview
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Product name
EX-527, SIRT1 Inhibitor -
Description
Selective SIRT1 Inhibitor -
Biological description
Selective, cell-permeable SIRT1 Inhibitor. (IC50= 98 nM, 19.6, 48.7 and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Shows no effect at other HDACs or SIRTs. Enhances p53 acetylation in response to DNA damaging agents. -
Purity
> 97% -
CAS Number
49843-98-3 -
Chemical structure
Properties
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Chemical name
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide -
Molecular weight
248.71 -
Molecular formula
C13H13ClN2O -
PubChem identifier
5113032 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
NC(=O)C2CCCc1c3cc(Cl)ccc3nc12 -
Source
Synthetic
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Research areas
Images
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Functional Studies - EX-527, SIRT1 Inhibitor (ab141506)Time course of SIRT1-substrate deacetylation by recombinant SIRT1 in the presence of EX-527.
References
This product has been referenced in:
- Choi HR et al. Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix. Aging Cell 10:148-57 (2011). Read more (PubMed: 21108727) »
- Solomon JM et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol 26:28-38 (2006). Read more (PubMed: 16354677) »
- Napper AD et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem 48:8045-54 (2005). Read more (PubMed: 16335928) »
