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    ex-527-sirt1-inhibitor-ab141506.pdf

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Cell Biology Apoptosis Intracellular p53 Pathway
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EX-527, SIRT1 Inhibitor (ab141506)

  • Datasheet
  • SDS
  • COA
Submit a review Submit a question References (3)

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Chemical Structure - EX-527, SIRT1 Inhibitor (ab141506)
  • Functional Studies - EX-527, SIRT1 Inhibitor (ab141506)

Key features and details

  • Selective SIRT1 Inhibitor
  • CAS Number: 49843-98-3
  • Purity: > 97%
  • Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    EX-527, SIRT1 Inhibitor
  • Description

    Selective SIRT1 Inhibitor
  • Biological description

    Selective, cell-permeable SIRT1 Inhibitor. (IC50= 98 nM, 19.6, 48.7 and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Shows no effect at other HDACs or SIRTs. Enhances p53 acetylation in response to DNA damaging agents.

  • Purity

    > 97%
  • CAS Number

    49843-98-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
  • Molecular weight

    248.71
  • Molecular formula

    C13H13ClN2O
  • PubChem identifier

    5113032
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    NC(=O)C2CCCc1c3cc(Cl)ccc3nc12
  • Source

    Synthetic

  • Research areas

    • Cell Biology
    • Apoptosis
    • Intracellular
    • p53 Pathway
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • Microbiology
    • Interspecies Interaction
    • Host Virus Interaction
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cytoskeleton
    • Microtubules
    • Tubulin
    • Tags & Cell Markers
    • Subcellular Markers
    • Nucleus
    • Other Nuclear Bodies
    • Cell Biology
    • Cell Cycle
    • Cell Division
    • Other cell division antibodies
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • HDACs
    • Class I
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Acetylation
    • HDACs
    • Class III / Sir2 class
    • Cancer
    • Oncoproteins/suppressors
    • Tumor suppressors
    • Other
    • Cardiovascular
    • Heart
    • Cardiac metabolism
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Metabolism
    • Types of disease
    • Obesity
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Deacetylase
    • Other
    • Biochemicals
    • Pharmacology
    • Signaling
    • Epigenetics
    • Histone Deacetylases (HDAC)
    • Biochemicals
    • Pharmacology
    • Enzymes
    • Deacetylase
    • Histone Deacetylase (HDAC)
    • Sirtuins (SIRT)
    • Biochemicals
    • Research Area
    • Cancer
    • Epigenetics
    • Histone Deacetylases (HDAC)
    • Biochemicals
    • Research Area
    • Epigenetics
    • Histone Deacetylases (HDAC)

Images

  • Chemical Structure - EX-527, SIRT1 Inhibitor (ab141506)
    Chemical Structure - EX-527, SIRT1 Inhibitor (ab141506)
    2D chemical structure image of ab141506, EX-527, SIRT1 Inhibitor
  • Functional Studies - EX-527, SIRT1 Inhibitor (ab141506)
    Functional Studies - EX-527, SIRT1 Inhibitor (ab141506)
    Time course of SIRT1-substrate deacetylation by recombinant SIRT1 in the presence of EX-527.

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (3)

Publishing research using ab141506? Please let us know so that we can cite the reference in this datasheet.

ab141506 has been referenced in 3 publications.

  • Zhang J  et al. N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation. J Diabetes Res 2020:1080152 (2020). PubMed: 32280711
  • Wu Y  et al. Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy. Mol Med Rep 22:2219-2226 (2020). PubMed: 32705226
  • Liu SP  et al. Secukinumab attenuates reactive astrogliosis via IL-17RA/(C/EBPß)/SIRT1 pathway in a rat model of germinal matrix hemorrhage. CNS Neurosci Ther N/A:N/A (2019). PubMed: 31020769

Customer reviews and Q&As

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