Product nameExendin-4 (Exenatide), GLP-1 receptor agonist
DescriptionPotent GLP-1 receptor agonist
- AC 2993
Biological descriptionHigh affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM).
SequenceHGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS (Modifications: C-terminal amide)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
This product has been referenced in:
- Thorens B et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42:1678-82 (1993). Read more (PubMed: 8405712) »
- Malhotra R et al. Exendin-4, a new peptide from Heloderma suspectum venom, potentiates cholecystokinin-induced amylase release from rat pancreatic acini. Regul Pept 41:149-56 (1992). Read more (PubMed: 1279756) »
- Eng J et al. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 267:7402-5 (1992). Read more (PubMed: 1313797) »