- References (1)
Product nameExendin (9-39) amide, GLP-1 receptor antagonist
DescriptionPotent, selective GLP-1 receptor antagonist
Biological descriptionPotent, selective GLP-1 receptor antagonist (Kd = 1.7 nM). Inhibits the generation of intracellular cAMP induced by GLP-1 (7-36), exendin-3 and exendin-4 (ab120214). Role in appetite modulation, water and salt homeostasis and insulin release. Active in vivo.
SequenceDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS (Modifications: C-terminal amide)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Peptide Receptors
- Glucagon and Related Receptors
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Integration of energy
This product has been referenced in:
- Voss U et al. Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons. BMC Gastroenterol 12:30 (2012). Read more (PubMed: 22463807) »
- Thorens B et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42:1678-82 (1993). Read more (PubMed: 8405712) »
- Raufman JP et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem 266:2897-902 (1991). Read more (PubMed: 1704369) »