Overview

  • Product name

    Exendin (9-39) amide, GLP-1 receptor antagonist
  • Description

    Potent, selective GLP-1 receptor antagonist
  • Biological description

    Potent, selective GLP-1 receptor antagonist (Kd = 1.7 nM). Inhibits the generation of intracellular cAMP induced by GLP-1 (7-36), exendin-3 and exendin-4 (ab120214). Role in appetite modulation, water and salt homeostasis and insulin release. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    133514-43-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Voss U  et al. Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are neuroprotective on cultured and mast cell co-cultured rat myenteric neurons. BMC Gastroenterol 12:30 (2012). Read more (PubMed: 22463807) »
  • Thorens B  et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42:1678-82 (1993). Read more (PubMed: 8405712) »
  • Raufman JP  et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem 266:2897-902 (1991). Read more (PubMed: 1704369) »
See 1 Publication for this product

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