Key features and details
- Rabbit polyclonal to EXOC7
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-EXOC7 antibody
See all EXOC7 primary antibodies
DescriptionRabbit polyclonal to EXOC7
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 74 and 345 of EXOC7 (NP_001013861; UniProt ID: Q9UPT5 isoform 1).
- WB: HeLa whole cell lysate; H1299, HepG2 and MOLT4 cell lysates ICC/IF: A431 cell
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab95981 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 78 kDa.|
|ICC/IF||1/100 - 1/200.|
FunctionComponent of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion.
Sequence similaritiesBelongs to the EXO70 family.
DomainThe N-terminus is involved in SEC8 and ARHQ binding.
The C-terminus is required for translocation to the plasma membrane.
Cellular localizationCytoplasm > cytosol. Cell membrane. Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ.
- Information by UniProt
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ab95981 has been referenced in 2 publications.
- Sáez JJ et al. The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells. J Cell Biol 218:2247-2264 (2019). PubMed: 31197029
- Arasaki K et al. Legionella remodels the plasma membrane-derived vacuole by utilizing exocyst components as tethers. J Cell Biol 217:3863-3872 (2018). PubMed: 30275106