Extra Standard for Interferon gamma ELISA Kit (ab59555)

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Overview

  • Product name

    Extra Standard for Interferon gamma ELISA Kit
    See all Interferon gamma kits

  • Assay type

    Sandwich

  • Product overview

    Extra Standard for Interferon gamma ELISA Kit (ab59555) is part of the Human IFN gamma ELISA Kit (ab46025). 


    Refer to the kit protocol booklet for instructions of use. Please contact our Scientific Support team for more lot specific information.

Properties

  • Storage instructions

    Store at +4°C. Please refer to protocols.

  • Research areas

  • Function

    Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

  • Tissue specificity

    Released primarily from activated T lymphocytes.

  • Involvement in disease

    In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.

  • Sequence similarities

    Belongs to the type II (or gamma) interferon family.

  • Post-translational
    modifications

    Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Alternative names

    • IF 1
    • IFG
    • IFI
    • IFN gamma
    • IFN immune
    • IFN, immune
    • IFN-gamma
    • IFNG
    • IFNG_HUMAN
    • Immune interferon
    • Interferon gamma
    • Type II Interferon
    see all

References

ab59555 has not yet been referenced specifically in any publications.

Publishing research using ab59555? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

Is ab 59555 suitable for use as a standard with the ab46025 kit?

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Answer

Yes, I can confirm you can use ab59555 Extra Standard for Interferon gamma ELISA Kit with ab46025 IFN gamma Human ELISA Kit.

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Question

Tell us, please, how many micrograms contains 1 unit of ab59555?

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Answer

The quantity of extra standard for ab46048 is batch dependent. Current batch of ab59555 has 400pg in the vial and needs to be reconsitutedin 1.0ml .

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Question

Hello, I am wondering if you could help me – we recently had an out of specification in our 2-8°C storage and are looking to assess the impact on products stored within the fridge. The maximum temperature reached was 10.5°C. The items affected are Human IFNy ELISA Kit Ab46045-1 Human IFNy Standard Ab59555-1 Any information on this matter would be greatly appreciated. Kind regards

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Answer

Thank you for your enquiry. I have received confirmation from the source of those products that we believe neither antibodies or other reagents will be affected by a temperature of 10.5°C. Please do not hesitate to contact us again if you need further assistance.

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